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The Daroff-Dell'Osso Ocular Motility Laboratory

An Endowed Laboratory of CASE School of Medicine and Case Western Reserve University
Located in the Louis Stokes Cleveland Department of Veterans Affairs Medical Center
Cleveland, Ohio, USA

Measurement of Human Eye Movements to Study Neurological, Visual, and Vestibular Disorders; Ocular Motor System Function and Dysfunction

Areas of Specialization: Systems and Computational Neurobiology, Ocular Motor Oscillations (Nystagmus and Saccadic), Ocular Motor System Models, Nystagmus Therapies, Vision and Balance, Vestibular Function, Version-Vergence Interaction, Eye-Head Interactions, and Retinal Electrophysiology of Visual Disorders
Measurement techniques: Infrared Reflection, Magnetic Search Coil, and High-Speed Digital Video Systems to record eye movements in the horizontal, vertical and torsional planes of humans; Motion Platform and Rotating Chairs to study balance.
Off-Site Research: Because the Daroff-Dell'Osso Ocular Motility Laboratory is designed for the study of human eye movements only, any non-human studies, e.g., on canines [COMLAB] and mice, have been carried out by specific investigators at other facilities in collaboration with investigators based at those facilities.

Information for EBME 318/319 students

Downloadable copies of the Theses, Book, Journal Articles, and Chapters of L.F. Dell'Osso

Nystagmus in Infancy and Childhood. Current Concepts in Mechanisms, Diagnoses, and Management
  by Richard W. Hertle and Louis F. Dell'Osso
(Flyer)   (Book Cover)   (Book and Appendices E and F with videos)

PubMed Links to Recent OMLAB Publications

RB Daroff    LF Dell'Osso     RJ Leigh    JS Stahl    MF Walker    JB Jacobs    A Serra

Nystagmus Lecture! Dell'Osso LF: A Half-Century of Research in Infantile Nystagmus Syndrome: Theoretical and Clinical Messages. Distinguished Guest Lecture

OMLAB Editorial! Dell'Osso LF: AGN Roadside Sobriety Test, DUI, and Childhood Nystagmus: A Charge with no Foundation, Test with Flawed Scientific Bases, and Trial that Never Should have Occurred. OMLAB Editorial #071021

Transcript of Expert Testimony in a DUI case based on the AGN Roadside Sobriety Test Administered to a Person with Childhood Nystagmus.

OMLAB Report! Dell'Osso LF: Simulation of Tunnel Acuity in INS. OMLAB Report #072020

Figures from Comment on CSNB nystagmus paper, 2019 Letter to the Editor: Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells.
[Go to "DUAL JERK (INS+NOT NYSTAGMUS) FIGURES" in Reports and Teaching]


1.History of the Daroff-Dell'Osso Ocular Motility Lab
          Canine OMlab: Research, Photos, Videos, and Data
  Canine Eye-Movement Data (In Progress):
    Achiasmatic Mutant Belgian Sheepdogs
    American Bulldog
    RPE65- Briards, and Miscellaneous

          Visit our Lab Space (includes our 2007 Conference)
          Ocular Motor Terminology and Conclusions
          The NAFX: an analysis method for visual acuity and nystagmus
          Ocular Motor Hypotheses: Support and Disproof
          Therapeutic Applications of our Research
          Diagnostic Criteria and Clinical Pearls

2. Personnel (Investigators, Visiting Scientists, Fellows, Students, Staff)

3. Software, Models, & Data
       OMtools Software (including NAFX)
       Ocular Motor System Models:
             Normal, INS, FMNS, Saccadic and Plant Disorders
       Eye-Movement Data:
            Published (2002-2014);
            OMLAB (S001-S347, 1986-2013);
       In Progress:
           RM Steinman (S001, 1984); Han Collewijn (AS001, 1993)

4. Reports & Teaching
        Eye-Movement Recording, Calibration, and NAFX; Therapies;
        Achiasma; Surgery; INS Model; INS Assessment; Other
        Patient Handouts:
           INS; INS Treatments; T&R; INS Acuity; Miscellaneous

5. Editorials: Ethical Science, INS Outcome Measures

6. Contact Information

OMtools has undergone major revisions. It has been thoroughly modernized to work with current and recent MATLAB versions, and is easier to install and configure. It can now import Eyelink EDF files (with free download of SR-Research's developer kit for Mac, Linux, or Windows). Check back for regular updates.

DD_OMLAB Dissertations available for download: PDFs of the PhD Dissertations of LF Dell'Osso, JB Jacobs, and ZI Wang. These contain the first OMS models to simulate normal function and both INS and FMNS.

DD_OMLAB Data! 557 de-identified and digitized eye-movement data sets from all of the 347 subjects recorded in our lab from 1986 to 2013 are now available for research and study.
Data recorded elsewhere will soon be added.

Last Data Upload: [Oct 16, 2018]
Spreadsheets Updated: [Dec 3, 2015]

OMLAB Report! Dell'Osso LF: Interesting Effects of a Monocular Epiretinal Membrane and Developing Cataracts in the Infantile Nystagmus Syndrome. OMLAB Report #071514

OMLAB Tutorial! Dell'Osso LF: Clinical INS Assessment to Determine Maximally Effective Therapy: What can the Physician Apply from the Bench to the Bedside? OMLAB Report #061214

Corrected Version! [May 31, 2013] OMS Model v1.5 User-Guide (Software)
Updated! [May 31, 2013] Latest updates and bug fixes to OMtools and NAFX (Software)
Click here to download OMS Models v1.5, v1.4, & v1.0

[May 21, 2010] NAFX can now evaluate biplanar nystagmus data and contains significant usability and speed enhancements

Note Added: [September 24, 2010]
Dell'Osso LF: Appropriate Outcome Measures for Infantile Nystagmus Therapies: "Science-based" not "Evidence-based" Studies. OMLAB Editorial #010410

Epilogue Added: [August 6, 2008]
Dell'Osso LF: INOS 2008 - Ethical Science or Something Else? OMLAB Editorial #071107
INOS Members Need to Knowinos2008 inos 2008

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